Dante (voice) / Dante / Boy (voice) / Dante / Mercenary #01 (voice) / Dante / Soldier #1 (voice)

Lady (voice) / Mary (voice) / Mary / Additional Voices (voice)

Vergil (voice) / Knight (voice) / Vergil / Horned Demon (voice)

Arkham / Agni / Rudra (voice) / Mundus / Arkham / Agent / Demon 3 (voice) / Mundus / Jester / Demon Noble 1 (voice) / Rudra / Demon Soldier (voice) / Mundus / News Anchor 2 / Sniper (voice) / Mundus / Jester (voice) / Mundus / Ringleader / Guard (voice) / Mundus / Jester / News Anchor 2 (voice) / Worker (voice)

White Rabbit (voice) / White Rabbit / Horned Demon (voice) / White Rabbit / Pilot (voice) / White Rabbit / Soldier #2 (voice) / Horned Demon (voice) / White Rabbit / News Anchor (voice)

Eva (voice) / Echidna / Demon Girl / Eva (voice) / Additional Voices (voice) / Eva / Baby (voice) / Eva / Echidna (voice) / Echidna (voice) / Eva . British News Reporter (voice)

Enzo (voice) / Enzo / Trucker (voice) / Enzo / Officer / Man (voice) / Enzo / Frat Boy (voice) / Enzo / Mercenary #03 (voice)

Arius (voice)

Young Dante (voice)

Mattie (voice)

Argosax / Sparda (voice)